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effects of lubricantmixing time on prolongation of

effects of lubricantmixing time on prolongation of

Effects of lubricant-mixing time on prolongation of ...

Effects of lubricant-mixing time on prolongation of dissolution time and its prediction by measuring near infrared spectra from tablets Drug Dev Ind Pharm . 2012 Apr;38(4):412-9. doi: 10.3109/03639045.2011.608679.

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Effects of lubricant-mixing time on prolongation of ...

Jan 05, 2011  (2012). Effects of lubricant-mixing time on prolongation of dissolution time and its prediction by measuring near infrared spectra from tablets. Drug Development and Industrial Pharmacy: Vol. 38, No. 4, pp. 412-419.

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Effects of lubricant-mixing time on prolongation of ...

May 01, 2012  With the extension of mixing time, T50 was prolonged. The Mg-St widely covered the surface of each particle of the bulk powder after material mixing. This coating effect may decrease the wettability of the particles and cause the prolongation of dissolution time.

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Effects of lubricant-mixing time on prolongation of ...

Effects of lubricant-mixing time on prolongation of dissolution time and its prediction by measuring near infrared spectra from tablets September 2011 Drug Development and Industrial Pharmacy 38(4 ...

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Effect of Mixing Time on the Lubricating Properties of ...

Effects of lubricant-mixing time on prolongation of dissolution time and its prediction by measuring near infrared spectra from tablets. ... With the extension of mixing time, T50 was prolonged ...

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Effects of lubricant mixing on compression properties of ...

Jan 01, 2004  Effects of mixer and mixing time on the tableting compression process Figure 2 shows the effect of mixer and mixing time of the lubricant on tensile strength of the tablets. The tensile strength (TS) of the tablets was evaluated by [17]: TS = 2F πDL , (4) where F is the tablet hardness, and D and L are diameter and thickness of the tablet ...

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Effects of lubricant-mixing time on prolongation of ...

Feb 24, 2012  (2012). Effects of lubricant-mixing time on prolongation of dissolution time and its prediction by measuring near infrared spectra from tablets. Drug Development and Industrial Pharmacy: Vol. 38, No. 4, pp. 412-419.

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Effect of Mixing Time on the Lubricating Properties of ...

Effects of lubricant-mixing time on prolongation of dissolution time and its prediction by measuring near infrared spectra from tablets. ... With the extension of mixing time, T50 was prolonged ...

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Effects of lubricant mixing on compression properties of ...

Jan 01, 2004  Effects of mixer and mixing time on the tableting compression process Figure 2 shows the effect of mixer and mixing time of the lubricant on tensile strength of the tablets. The tensile strength (TS) of the tablets was evaluated by [17]: TS = 2F πDL , (4) where F is the tablet hardness, and D and L are diameter and thickness of the tablet ...

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Effect of mixing time on the lubricating properties of ...

AbstractThe effect of mixing time on hardness, disintegration time and ejection force in tablettlng of magnesium stearate and lactose granules was studied. The hardness of the tablets decreased with an increase in mixing time of the blends, as previously reported. A semilogarithmic plot of the hardness versus mixing time gave a straight line having a turning point.

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Effects of lubricant mixing on compression properties of ...

The effect of mixing time and its potential to cause overlubrication are well characterized in the literature. 7, 17, 18 As mixing time increases, the negative effects of lubrication on granule ...

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Effects of prolongation of overall treatment time due to ...

The prescribed total radiation dose should be administered within a specific time. In daily clinical practice, however, unplanned treatment interruptions resulting in prolongation of the overall treatment time are predictable. The present review evaluated the existing published data regarding the af

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Tablet Characteristics Prediction by Powder Blending ...

Jan 01, 2013  Abe, H. and Otsuka, M. , “Effects of lubricant-mixing time on prolongation of dissolution time and its prediction by measuring near infrared spectra from tablets”, Drug Dev. Ind. Pharm. 38(4), 4 – 12 (2011).

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Effect of Mixing on the Lubrication of Crystalline Lactose ...

A mathematical expression for tablet hardness was related to lubricant mixing by considering increases in the surface coverage with prolonged mixing time. The duration of lubricant mixing ...

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Effect of Particle Size on Compaction of Materials with ...

Feb 28, 2008  This causes a decrease in compact strength, especially with excessive lubricant amounts and/or prolonged mixing times (1,8,9). The effect of lubricant on compact strength depends on a number of factors such as its nature , concentration, mixing time (3,10), and specific surface area .

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JZUS - Journal of Zhejiang University SCIENCE

Effects of lubricant-mixing time on prolongation of dissolution time and its prediction by measuring near infrared spectra from tablets. Drug Dev Ind Pharm, 38(4):412-419. [2]Barone A, Glassey J, Montague G, 2019. Towards online near-infrared spectroscopy to optimise food product mixing.

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Effects of storage time prolongation on in vivo and in ...

Effects of storage time prolongation on in vivo and in vitro characteristics of 4°C-stored platelets Transfusion. 2020 Mar;60(3):613-621. doi: 10.1111/trf.15669. Epub 2020 Feb 4.

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Evaluation and comparison of magnesium stearate and sodium ...

These effects are known to increase with prolonged mixing, and in practice one tries to keep the lubricant mixing time as short as possible (Ragnarsson et al., 1979:130). It has been shown that the die wall film of magnesium stearate is resistant to wearing off and the lubricating effect remains for several compactions when an unlubricated ...

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Effect of Prolonged Radiotherapy Treatment Time on ...

Purpose: To estimate the influence of prolonged radiation treatment time (RTT) on survival outcomes in nasopharyngeal carcinoma after continuous intensity-modulated radiation therapy. Methods and materials: Retrospectively review 321 patients with NPC treated between October 2009 and December 2010 and all of them underwent simultaneous accelerated intensity-modulated radiation therapy.

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Mechanism of surface lubrication: influence of duration of ...

A mathematical expression for tablet hardness was related to lubricant mixing by considering increases in the surface coverage with prolonged mixing time. The duration of lubricant mixing significantly changed the apparent bulk volume of the mix, ejection force during tableting, hardness, and disintegration and dissolution properties of tablets.

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Effect of mixing time on the lubricating properties of ...

AbstractThe effect of mixing time on hardness, disintegration time and ejection force in tablettlng of magnesium stearate and lactose granules was studied. The hardness of the tablets decreased with an increase in mixing time of the blends, as previously reported. A semilogarithmic plot of the hardness versus mixing time gave a straight line having a turning point.

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Effects of lubricant mixing on compression properties of ...

The tablet hardness of MCC decreased with an increase in mixing time in the high-speed mixer and the related compression properties of MCC changed depending on the hardness, but those of DCPA did not. The order of the effect of mixing was MCC > SDL > DCPA and the high-speed mixer was more effective than the twin-shell mixer.

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Superior Lubrication Performance of Sodium Stearyl Fumarate

Sep 22, 2020  mixing time (2-step addition), nearly independently of the amount used and the presence of colloidal silica. In the case of prolonged mixing in the presence of the lubricant (1-step addition), the benefits of SSF (Alubra®) are seen predominantly in combination with co-processed SMCC or at lubricant addition levels ~2% in case of externally ...

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Evaluation and comparison of magnesium stearate and sodium ...

These effects are known to increase with prolonged mixing, and in practice one tries to keep the lubricant mixing time as short as possible (Ragnarsson et al., 1979:130). It has been shown that the die wall film of magnesium stearate is resistant to wearing off and the lubricating effect remains for several compactions when an unlubricated ...

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Dissociation of antithrombotic effect and bleeding time ...

The effect of the inhibitors on the hemostatic system was studied in a separate set of rabbits by measuring template bleeding times (BT) in the ear arterioles, marginal ear vein and the nail cuticle of the foreleg. AP-1 and napsagatran showed a similar antithrombotic activity (78% and 80% abolition of the CFVs, respectively), whereas either low ...

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The Physiological Effects of Prolonged PPE Use During Long ...

Jul 28, 2020  NIOSH and the CDC discuss the burden many healthcare workers face with prolonged use of PPE during long shifts. If your workers are required to wear PPE for long periods of time

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Long-Term Effects of Antidepressants - Verywell Mind

Feb 19, 2021  However, many other side effects can continue long term and can have a negative impact on your quality of life. In 2016, the medical journal Patient Preference and Adherence published a paper looking at what people taking antidepressants long-term had to say about the side effects

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The Harmful Effects of Too Much Screen Time for Kids

Sep 17, 2020  Obesity : Too much time engaging in sedentary activity, such as watching TV and playing video games, can be a risk factor for becoming overweight. 1 . Sleep problems : Although many parents use TV to wind down before bed, screen time before bed can backfire. The light emitted from screens interferes with the sleep cycle in the brain and can ...

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Seroquel Side Effects: Common, Severe, Long Term - Drugs

Jul 22, 2020  While these effects have been shown as a class effect, each agent has its own profile. Hyperglycemia: Adults: In controlled clinical trials of 12 weeks or less, 2.4% of patients with normal (less than 100 mg/dL) fasting plasma glucose (FPG) had at least 1 FPG reading of 126 mg/dL or greater (vs. placebo 1.4%) during treatment.

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Drug-excipient interactions resulting from powder mixing ...

After prolonged mixing, sodium stearyl fumarate did not interact with the drug or excipients; as a result, the disintegration time and Two lubricants, magnesium stearate and sodium stearyl fumarate, were compared under identical mixing conditions to study their roles in drug-excipient interactions.

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Towards reliable optimization of metal powder—Lubricant ...

Request PDF Towards reliable optimization of metal powder—Lubricant mixing for high die filling performance: Exploring a rheology based approach A previously unreported approach to optimize ...

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Effect of Particle Size on Compaction of Materials with ...

Feb 28, 2008  This work investigates the effect of excipient particle size on compaction properties of brittle, plastic and viscoelastic materials with and without added lubricants. Sieve cuts of Microcrystalline cellulose (MCC), Starch and Dibasic calcium phosphate dihydrate were obtained by sieving, then samples were tested without lubrication or with added lubricant (0.5% Mg stearate mixed for either 5 ...

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OATD: Louw, Ruaan - Evaluation and comparison of magnesium ...

Jun 14, 2017  Due to the deleterious effects on the tablet properties, lubricant concentrations must be restricted to an absolute minimum. These effects are known to increase with prolonged mixing, and in practice one tries to keep the lubricant mixing time as short as possible (Ragnarsson et al., 1979:130).

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